Christa E Müller Selected Research

Uridine Triphosphate (UTP)

1/2022	Discovery of P2Y2 Receptor Antagonist Scaffolds through Virtual High-Throughput Screening.
7/2018	Mechanism underlying the contractile activity of UTP in the mammalian heart.
1/2017	Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor.
1/2017	Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925.
12/2013	P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo.
11/2006	Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.

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Christa E Müller Research Topics

Disease

43	Neoplasms (Cancer) 10/2022 - 01/2003
25	Inflammation (Inflammations) 03/2022 - 03/2008
17	Parkinson Disease (Parkinson's Disease) 01/2021 - 05/2004
12	Astrocytoma (Pilocytic Astrocytoma) 11/2020 - 03/2005
11	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2022 - 01/2007
10	Pain (Aches) 01/2022 - 01/2006
8	Alzheimer Disease (Alzheimer's Disease) 07/2022 - 04/2008
7	Neuralgia (Stump Neuralgia) 11/2019 - 06/2010
7	Tremor (Tremors) 01/2016 - 01/2008
6	Memory Disorders (Memory Loss) 01/2019 - 04/2008
6	Parkinsonian Disorders (Parkinsonism) 01/2016 - 01/2008
5	Chronic Pain 01/2021 - 12/2012
5	Neuroblastoma 02/2008 - 04/2002
5	Glioma (Gliomas) 02/2008 - 04/2002
4	Obesity 01/2022 - 12/2014
4	Stroke (Strokes) 12/2020 - 01/2003
4	Hyperalgesia 01/2019 - 01/2004
4	Neuroinflammatory Diseases 01/2018 - 05/2014
4	Ischemia 10/2017 - 09/2007
3	Infections 12/2021 - 01/2016
3	Hypoxia (Hypoxemia) 05/2021 - 12/2012
3	Asthma (Bronchial Asthma) 04/2021 - 01/2003
3	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2016
3	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 01/2016
3	Dyskinesias (Dyskinesia) 01/2021 - 03/2014
3	Nephrogenic Diabetes Insipidus 01/2017 - 12/2015
3	Polyuria 01/2017 - 12/2015
3	Melanoma (Melanoma, Malignant) 12/2015 - 02/2008
2	Cognitive Dysfunction 07/2022 - 11/2016
2	Dementia (Dementias) 07/2022 - 06/2019
2	Vascular Remodeling 02/2022 - 01/2019
2	COVID-19 01/2022 - 01/2021
2	Brain Diseases (Brain Disorder) 01/2022 - 01/2018
2	Wounds and Injuries (Trauma) 11/2021 - 01/2017
2	Pathologic Processes 05/2021 - 04/2020
2	Edema (Dropsy) 03/2021 - 03/2008
2	Chronic Cough 01/2021 - 11/2019
2	Dry Eye Syndromes (Dry Eye Syndrome) 01/2020 - 01/2006
2	Lung Diseases (Lung Disease) 01/2020 - 09/2017
2	Arthritis (Polyarthritis) 11/2019 - 03/2014

Drug/Important Bio-Agent (IBA)

36	Adenosine (Adenocard)FDA LinkGeneric 02/2022 - 11/2003
23	Pharmaceutical PreparationsIBA 01/2022 - 01/2007
15	Adenosine Triphosphate (ATP)IBA 02/2022 - 10/2007
12	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2022 - 11/2003
12	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2022 - 01/2007
9	NucleosidesIBA 01/2021 - 09/2007
9	EnzymesIBA 12/2020 - 06/2005
8	LigandsIBA 03/2021 - 01/2009
8	Caffeine (No Doz)FDA LinkGeneric 03/2018 - 04/2008
7	CannabinoidsIBA 03/2022 - 07/2011
7	NucleotidesIBA 10/2018 - 04/2002
6	Uridine Triphosphate (UTP)IBA 01/2022 - 11/2006
6	CytokinesIBA 11/2021 - 02/2014
6	CalciumIBA 11/2020 - 02/2008
6	triphosphoric acid (triphosphate)IBA 01/2020 - 09/2007
5	Adenosine A2B ReceptorIBA 06/2022 - 08/2011
5	Purinergic P2Y2 ReceptorsIBA 01/2022 - 01/2006
5	Adenosine Diphosphate (ADP)IBA 01/2019 - 10/2007
5	Adenine FDA LinkGeneric 09/2013 - 03/2005
5	Purinergic P1 Receptor AntagonistsIBA 12/2011 - 01/2004
4	5'-Nucleotidase (5' Nucleotidase)IBA 07/2021 - 02/2008
4	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 03/2014
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021 - 06/2013
4	Dopamine (Intropin)FDA LinkGeneric 01/2020 - 01/2008
4	Proteins (Proteins, Gene)FDA Link 03/2018 - 03/2011
4	Clopidogrel (Plavix)FDA Link 01/2017 - 07/2012
4	Cholinergic Agents (Cholinergics)IBA 01/2016 - 02/2010
3	Retinaldehyde (Retinal)IBA 02/2022 - 10/2017
3	Gq-G11 GTP-Binding Protein alpha Subunits (Gq Protein)IBA 01/2022 - 01/2017
3	Purinergic P2X7 ReceptorsIBA 01/2022 - 01/2016
3	GTP-Binding Proteins (G-Protein)IBA 01/2022 - 04/2021
3	NucleotidasesIBA 07/2021 - 01/2012
3	Adenosine A2 Receptor AntagonistsIBA 03/2021 - 04/2008
3	Adenosine Monophosphate (AMP)IBA 01/2020 - 10/2007
3	CD39 antigenIBA 01/2020 - 10/2007
3	Messenger RNA (mRNA)IBA 01/2020 - 02/2008
3	Monoamine Oxidase (MAO)IBA 01/2020 - 06/2013
3	purineIBA 01/2019 - 04/2002
3	ectoATPaseIBA 01/2019 - 08/2008
3	Purinergic P2X4 ReceptorsIBA 01/2019 - 11/2012
3	UracilIBA 10/2018 - 01/2006
3	Apyrase (ATP Diphosphatase)IBA 09/2017 - 09/2007
3	Prasugrel Hydrochloride FDA Link 01/2017 - 07/2012
3	LithiumIBA 01/2017 - 12/2015
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2016 - 09/2011
3	Galantamine (Galanthamine)FDA LinkGeneric 01/2016 - 09/2011
3	ProdrugsIBA 05/2014 - 12/2009
2	Amyloid (Amyloid Fibrils)IBA 07/2022 - 01/2018
2	psb-603IBA 05/2021 - 03/2021
2	XanthineIBA 05/2021 - 08/2014
2	Interleukin-6 (Interleukin 6)IBA 03/2021 - 10/2016
2	CarrageenanIBA 03/2021 - 03/2008
2	Ion Channels (Ion Channel)IBA 11/2020 - 02/2017
2	purinoceptor P2Y4IBA 01/2020 - 01/2017
2	Insulin ReceptorIBA 01/2020 - 05/2017
2	Neuroprotective AgentsIBA 01/2020 - 03/2008
2	Purinergic P2X3 ReceptorsIBA 11/2019 - 04/2019

Therapy/Procedure

26	Therapeutics 01/2022 - 01/2003
9	Immunotherapy 10/2022 - 08/2012
2	Drug Therapy (Chemotherapy) 07/2019 - 03/2011